N2 Supplement-A, containing iron-rich human transferrin, was developed for the in vitro differentiation of mouse or human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells to neural and pancreatic-like cell types. Different neuronal subtypes can be generated when human ES/iPS cell-derived neural progenitor cells are cultured in BrainPhys™ Neuronal Medium (Catalog #05790) supplemented with N2 Supplement-A, NeuroCult™ SM1 Neuronal Supplement (Catalog #05711), and other factors. N2 Supplement-A is provided as a 100X stock solution. N2 Supplement-A is available for individual sale or as a component of the BrainPhys™ Neuronal Medium N2-A & SM1 Kit (Catalog #05793).