DAPT is an inhibitor of the γ-secretase complex. Notch is a key target of γ-secretase, therefore DAPT indirectly inhibits the Notch pathway. Other targets of γ-secretase that would be influenced by DAPT include amyloid precursor protein, E-cadherin, and ErbB4. (Dovey et al.). MAINTENANCE AND SELF-RENEWAL · Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al.). · Enhances radiation-induced cell death of glioma stem cells (Wang et al.). DIFFERENTIATION · Promotes differentiation of nociceptors from human pluripotent stem cells, in combination with several other small molecules (Chambers et al.). · 微信同号 二维码如下 ·